Steve Holland, aged 59, who is from Thatcham, was last seen leaving the Slug and Lettuce pub in Wharf Street, Newbury, at about 11.15pm on Friday (8/12).
After leaving the pub he walked towards the wharf and has not been seen since.
Investigating officer, Detective Inspector Jonathan Groenen of Force CID of Newbury Police Station, said: “I am very concerned for Steve’s welfare, he has not made contact with anyone since Friday night and has not turned up for work yesterday.
“Steve is a white man, of medium build, about 5ft 8ins, with short, receding dark brown hair.
“When he was last seen he was wearing black jeans and a black jacket with a stripey jumper underneath.
“Anyone with any information regarding Steve’s whereabouts is asked to contact police immediately by calling 101 and quoting reference 690 (11/12).”